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Prevalencia y severidad de la hipertensión pulmonar en residentes rurales asintomáticos con infección por esquistosoma en el Delta del Nilo
Author(s) -
Farrag Azza,
ElAroussy Wafaa,
Zaghloul Salah,
ElGuindy Mohamed,
Yacoub Magdi
Publication year - 2012
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2011.02891.x
Subject(s) - asymptomatic , medicine , nile delta , schistosomiasis , pulmonary hypertension , ejection fraction , cardiology , immunology , heart failure , ancient history , helminths , history
Objectives Millions of people in the developing world may suffer from pulmonary hypertension (PHTN) because of preexisting infectious conditions. Schistosomiasis can cause pulmonary lesions that eventually lead to PHTN. The aim of this study was to assess the prevalence of PHTN together with assessment of right ventricular (RV) function in asymptomatic rural residents previously infected with schistosomiasis. Methods Three hundred and seventy asymptomatic people from an endemic area in the Nile Delta were screened for antibodies against schistosomiasis. All were scheduled for transthoracic echocardiographic study to assess pulmonary artery systolic (PASP) and diastolic (PADP) pressures as well as RV function. PASP >40 mmHg was considered elevated. Results Seropositive (SP) and seronegative (SN) groups had comparable age and body mass index. PASP >40 mmHg was met in 18 subjects (Range 42–72 mmHg) (8.6%) of SP group and in no subject in SN group ( P = 0.000). Compared with SN group, the SP group had higher mean values of PASP (30 ± 10 vs . 24 ± 7 mmHg, P < 0.000) and PADP (12 ± 4 vs . 9 ± 3 mmHg, P < 0.000). The SP group had lower values of RV ejection fraction. Conclusion Prevalence of PHTN as detected by echocardiography in asymptomatic rural residents with schistosomiasis in Nile Delta is low with mild affection of RV function.