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Precisión de la prueba del antígeno catódico circulante para el mapeo rápido de infecciones por Schistosoma mansoni y S. haematobium en el sur de Sudán
Author(s) -
Ashton Ruth A.,
Stewart Barclay T.,
Petty Nora,
Lado Mounir,
Finn Timothy,
Brooker Simon,
Kolaczinski Jan H.
Publication year - 2011
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2011.02815.x
Subject(s) - schistosoma haematobium , schistosomiasis , dipstick , schistosoma mansoni , urine , helminthiasis , gold standard (test) , trematoda , immunology , antigen , medicine , biology , virology , helminths
Summary Objective To evaluate the diagnostic accuracy of a circulating cathodic antigen (CCA) urine dipstick test for detecting Schistosoma mansoni and S. haematobium alongside an integrated rapid mapping survey in Southern Sudan. Methods and Results A total of 373 children aged 5–16 years were included in the study. Of these 26.0% were infected with S. haematobium and 24.5% were infected with S. mansoni , as identified by urine filtration or single Kato–Katz thick smear, respectively. The CCA performed moderately in detecting S. mansoni , with sensitivity of 89.1% and specificity of 74.2%, and poorly in detecting S. haematobium infections, with a sensitivity of 36.8% and specificity of 78.9%. This may be a slight underestimate of true CCA accuracy, since only single stool and urine samples were examined by microscopy. The true ‘gold standard’ for comparison would have been the collection of multiple stool samples over consecutive days. Conclusion The poor CCA accuracy for diagnosis of urinary schistosomiasis means that this test is currently not suitable for rapid mapping of schistosomiasis in areas where both S. mansoni and S. haematobium may be endemic.