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Infecciones Respiratorias Virales Agudas en niños atendidos en un hospital rural en el sur de Mozambique
Author(s) -
O’CallaghanGordo Cristina,
DíezPadrisa Núria,
Abacassamo Fatima,
PérezBreña Pilar,
Casas Inmaculada,
Alonso Pedro L.,
Roca Anna
Publication year - 2011
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2011.02811.x
Subject(s) - human metapneumovirus , medicine , rhinovirus , epidemiology , pediatrics , respiratory system , odds ratio , respiratory tract infections , enterovirus , virus , respiratory infection , virology
Summary Objectives To determine the epidemiology and clinical presentation of virus‐associated acute respiratory infections (ARI) in Mozambican infants. Methods A systematic selection of nasopharyngeal aspirates ( n = 333), collected from infants younger than 12 months who visited Manhiça District Hospital (southern Mozambique) with ARI during a 12 months respiratory syncitial virus surveillance, were tested for other common respiratory viruses. Four different polymerase chain reactions were used to diagnose rhinovirus (RV), influenza (Flu; A and B), adenovirus (ADV), human metapneumovirus (hMPV), parainfluenza (PIV; 1, 2, 3 and 4AB) and enterovirus (EV). Results At least one study virus was identified in more than half of the samples tested (185/333). Overall, 231 viruses were detected among 185 infants, listed in the order of prevalence: RV (26%), Flu (15%), ADV (14%), hMPV (7%), PIV (5%) and EV (3%). Acute respiratory infections (ARI) cases and viral episodes were seasonal and concentrate during the warm and the rainy season. Clinical features were similar among all study children regardless of the detection of virus, with the exception of ear discharge, which was more frequent among viral cases [6% (11/183) vs. 1% (2/144); P = 0.034]. Children with multiple viral infections had higher odds of severity such as nasal flaring and indrawing (OR = 2.7, P = 0.028 and OR = 3.8, P = 0.007, respectively) and higher odds of hospitalisation (OR = 4.42, P = 0.001, adjusted by age and sex). Conclusions Viral ARI are frequent among infants visited in MHD. Strategies to prevent mild respiratory infections, and specially their complications, might alleviate health systems of source‐limited settings.