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Intervalos de referencia hematológicos y bioquímicos para bebes y niños en Gabón
Author(s) -
Humberg Alexander,
Kammer Judith,
Mordmüller Benjamin,
Kremsner Peter G.,
Lell Bertrand
Publication year - 2011
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2010.02705.x
Subject(s) - medicine , pediatrics
Summary Objectives To establish reference intervals for major haematological and biochemical parameters in Gabonese infants and children. Methods The reference sample population consisted of 226 healthy infants (4–9 weeks of age) and 185 healthy children (18–60 months of age). Basic red cell parameters as well as total and differential white blood cell counts were performed. Clinical chemistry parameters consisted of glutamate–pyruvic transaminase and creatinine, and total bilirubin was measured in children. Statistical analysis was based on the guidelines of the Clinical and Laboratory Standards Institute. Nonparametric methods were used to determine 95% reference limits and their 90% confidence intervals. Results Compared to European populations, values for several red cell parameters (haemoglobin, haematocrit, red blood cell count, mean corpuscular volume) were lower and platelet counts were higher. Eosinophils were higher in the older age group, most likely caused by intestinal helminths. Conclusions The study confirms the importance of establishing reference limits for local populations. The reference ranges could be used as a benchmark for similar populations in Central Africa.