Premium
Virologic outcomes of first‐line HAART and associated factors among Chinese patients with HIV in three sentinel antiretroviral treatment sites
Author(s) -
Ruan Yuhua,
Xing Hui,
Wang Xia,
Tang Heng,
Wang Zhe,
Liu Hongwei,
Su Bin,
Wu Jianjun,
Li Hanping,
Liao Lingjie,
Li Jingyun,
Wu Julia Wei,
Shao Yiming
Publication year - 2010
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2010.02621.x
Subject(s) - medicine , hiv drug resistance , antiretroviral therapy , viral load , human immunodeficiency virus (hiv) , drug resistance , antiretroviral drug , cohort study , prospective cohort study , young adult , virology , biology , microbiology and biotechnology
Summary Objective To evaluate HIV drug resistance (HIVDR) among Chinese patients with HIV receiving first‐line highly active antiretroviral therapy (HAART). Methods Based on the WHO HIVDR surveys, a prospective cohort study with 12‐month follow‐up was conducted to estimate the prevalence of HIV RNA < 1000 copies/ml and HIVDR. Results A total of 341 study subjects naïve to prior antiretroviral therapy (ART) were followed up for a median of 12.1 months. The overall mortality rate was 9.9 per 100 person‐years. The median of CD4 counts increased from 182 cells/mm 3 at baseline to 268 cells/mm 3 at 12 months ( P < 0.0001). Of patients with plasma HIV‐1 RNA concentrations ≥1000 copies/ml at 12 months, the proportions of resistance to non‐nucleoside reverse transcriptase drugs, nucleoside/nucleotide reverse transcriptase inhibitors, and protease inhibitor drugs were 34.2%, 23.7% and 0%, respectively. The overall proportion of HIV RNA < 1000 copies/ml was 85.7% at 12 months. Occupation of farmer (AOR = 0.3, 95% CI: 0.08, 0.94; P = 0.0393) and HAART counselling and instruction through telephone (AOR = 2.8, 95% CI: 1.4, 5.6; P = 0.0047) were significantly associated with HIV RNA < 1000 copies/ml. Conclusion Our study demonstrated that the community‐based ART had significant effects on viral suppression and immune recovery. HIVDR should be monitored in the long term to guide informed decisions on preventing HIVDR and choices of first‐ and second‐line regimens.