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First attempt to validate the gSG6‐P1 salivary peptide as an immuno‐epidemiological tool for evaluating human exposure to Anopheles funestus bites
Author(s) -
Poinsig Anne,
Samb Badara,
Doucoure Souleymane,
Drame PapaMakhtar,
Sarr Jean Biram,
Sow Cheikh,
Cornelie Sylvie,
Maiga Sophie,
Thiam Cheikh,
Rogerie François,
Guindo Sohidou,
Hermann Emmanuel,
Simondon François,
Dia Ibrahima,
Riveau Gilles,
Konate Lassana,
Remoue Franck
Publication year - 2010
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2010.02611.x
Subject(s) - biomarker , malaria , anopheles gambiae , biology , anopheles , plasmodium falciparum , immunology , biochemistry
Summary Objective The development of a biomarker of exposure based on the evaluation of the human antibody response specific to Anopheles salivary proteins seems promising in improving malaria control. The IgG response specific to the gSG6‐P1 peptide has already been validated as a biomarker of An. gambiae exposure. This study represents a first attempt to validate the gSG6‐P1 peptide as an epidemiological tool evaluating exposure to An. funestus bites, the second main malaria vector in sub‐Saharan Africa. Methods A multi‐disciplinary survey was performed in a Senegalese village where An. funestus represents the principal anopheline species. The IgG antibody level specific to gSG6‐P1 was evaluated and compared in the same children before, at the peak and after the rainy season. Results Two‐thirds of the children developed a specific IgG response to gSG6‐P1 during the study period and – more interestingly – before the rainy season, when An. funestus was the only anopheline species reported. The specific IgG response increased during the An. funestus exposure season, and a positive association between the IgG level and the level of exposure to An. funestus bites was observed. Conclusions The results suggest that the evaluation of the IgG response specific to gSG6‐P1 in children could also represent a biomarker of exposure to An. funestus bites. The availability of such a biomarker evaluating the exposure to both main Plasmodium falciparum vectors in Africa could be particularly relevant as a direct criterion for the evaluation of the efficacy of vector control strategies.