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Epidemiología y carga de enfermedad de la encefalitis japonesa en Cambodia: Resultados de dos años de vigilancia centinela
Author(s) -
Touch Sok,
Hills Susan,
Sokhal Buth,
Samnang Chham,
Sovann Ly,
Khieu Virak,
Soeung Sann Chan,
Toda Kohei,
Robinson Jaimie,
Grundy John
Publication year - 2009
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2009.02380.x
Subject(s) - meningoencephalitis , medicine , epidemiology , pediatrics , japanese encephalitis , dengue fever , encephalitis , virology , virus
Summary Objectives To describe the results from two years of Japanese encephalitis (JE) sentinel surveillance in Cambodia. Methods Sentinel site surveillance for JE in children aged 15 years and under was implemented in Cambodia in mid‐2006. It was integrated into the routine meningoencephalitis surveillance system. Six hospitals were selected as sentinel sites. Epidemiological information and diagnostic specimens were collected from each patient presenting with meningoencephalitis. Cerebrospinal fluid and sera were tested for presence of immunoglobulin M antibodies against JE and dengue viruses by an ELISA. Surveillance data from 2006 to 2008 were analysed. Results Of 586 patients presenting with meningoencephalitis, 110 (19%) were confirmed to have JE. The percentage of confirmed JE cases at individual sentinel sites ranged from 13% to 35% of all meningoencephalitis cases. Mean age was 6.2 years, with 95% of JE cases in children aged 12 years and under. Cases occurred year‐round in both 12‐month reporting periods. Conclusions JE is an important cause of meningoencephalitis in Cambodian children. As JE is a vaccine‐preventable disease, an immunization programme could result in a considerable reduction in morbidity and mortality from JE among children in Cambodia.