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Frecuencia de la mutación Val1016Ile en el gen del canal de sodio dependiente del voltaje de poblaciones brasileras de Aedes aegypti
Author(s) -
Martins Ademir Jesus,
Lima José Bento Pereira,
Peixoto Alexandre Afranio,
Valle Denise
Publication year - 2009
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2009.02378.x
Subject(s) - knockdown resistance , aedes aegypti , pyrethroid , biology , genotyping , sodium channel , mutation , genetics , insecticide resistance , genotype , gene , toxicology , pesticide , ecology , sodium , larva , chemistry , cyfluthrin , organic chemistry
Summary One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage‐gated sodium channel (Na v ). In Aedes aegypti , the Val1016Ile substitution of the AaNa v gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.