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Transmission of SARS in three Chinese hospitals
Author(s) -
Cooper Ben S.,
Fang LiQun,
Zhou JiePing,
Feng Dan,
Lv Hui,
Wei MaoTi,
Wang ShiXin,
Cao WuChun,
De Vlas Sake J.
Publication year - 2009
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2009.02346.x
Subject(s) - outbreak , medicine , mainland china , transmission (telecommunications) , beijing , epidemiology , attack rate , transmissibility (structural dynamics) , logistic regression , infection control , emergency medicine , china , basic reproduction number , environmental health , demography , geography , population , intensive care medicine , virology , physics , electrical engineering , archaeology , engineering , vibration isolation , quantum mechanics , sociology , vibration
Summary Objective To quantify the transmissibility of severe acute respiratory syndrome (SARS) in hospitals in mainland China and to assess the effectiveness of control measures. Methods We report key epidemiological details of three major hospital outbreaks of SARS in mainland China, and estimate the evolution of the effective reproduction number in each of the three hospitals during the course of the outbreaks. Results The three successive hospital outbreaks infected 41, 99 and 91 people of whom 37%, 60% and 70% were hospital staff. These cases resulted in 33 deaths, five of which occurred in hospital staff. In a multivariate logistic regression, age and whether or not the case was a healthcare worker (HCW) were found to be significant predictors of mortality. The estimated effective reproduction numbers (95% CI) for the three epidemics peaked at 8 (5, 11), 9 (4, 14) and 12 (7, 17). In all three hospitals the epidemics were rapidly controlled, bringing the reproduction number below one within 25, 10 and 5 days respectively. Conclusions This work shows that in three major hospital epidemics in Beijing and Tianjin substantially higher rates of transmission were initially observed than those seen in the community. In all three cases the hospital epidemics were rapidly brought under control, with the time to successful control becoming shorter in each successive outbreak.