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Estudios epidemiológicos de los efectos “no‐específicos” de las vacunas: II – cuestiones metodológicas en el diseño y análisis de estudios de cohortes.
Author(s) -
Farrington C. P.,
Firth M. J.,
Moulton L. H.,
Ravn H.,
Andersen P. K.,
Evans S.
Publication year - 2009
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2009.02302.x
Subject(s) - epidemiology , selection bias , medicine , cohort study , cohort , clinical study design , selection (genetic algorithm) , affect (linguistics) , environmental health , information bias , psychology , clinical trial , computer science , pathology , communication , artificial intelligence
Summary We review sources of bias which can affect non‐randomized cohort studies of non‐specific effects of vaccines on child mortality. Using examples from the literature on non‐specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.