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Exposición temprana a la vacuna de la fiebre amarilla durante el embarazo
Author(s) -
Cavalcanti Denise P.,
Salomão Maria Antonieta,
LopezCamelo Jorge,
Pessoto Mônica A.
Publication year - 2007
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2007.01851.x
Subject(s) - medicine , pregnancy , yellow fever , vaccination , population , yellow fever vaccine , obstetrics , pediatrics , immunology , environmental health , virus , biology , genetics
Summary Objective To investigate the association of Yellow Fever Vaccination (YFV) during pregnancy with the presence of structural defect in exposed babies. Methods An observed/expected frequencies study, before and after the vaccination campaign against YF was designed. 304 babies exposed to YFV during the prenatal period underwent dysmorphological examinations. The expected frequencies of malformations were obtained from a reference population of 10 691 births occurred in the period immediately prior to the vaccination campaign and born in the same region. These frequencies were evaluated using Poisson distribution model. Results The major malformation rate found in this study was 3.3% (CI 1.7–6.3%). Minor dysmorphisms, especially naevus, were significantly more frequent ( P < 0.001) than in the reference population. Conclusions The data here presented provide no indication that immunization with YFV early in pregnancy increases the risk of major malformations. However, the association found between YFV during pregnancy and minor dysmorphisms, especially pigmented naevus, seems to be a bias of evaluation. We suggest, nevertheless, that a reproductive risk hypothesis regarding minor dysmorphisms should be considered in future studies involving YFV.