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Estudio correlativo de ultrasonido y serología en un área de China co‐endémica para echinococcosis alveolar humana y quística
Author(s) -
Yang Y. R.,
Craig P. S.,
Ito A.,
Vuitton D. A.,
Giraudoux P.,
Sun T.,
Williams G. M.,
Huang Z.,
Li Z.,
Wang Y.,
Teng J.,
Li Y.,
Huang L.,
Wen H.,
Jones M. K.,
McManus D. P.
Publication year - 2007
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2007.01834.x
Subject(s) - cystic echinococcosis , alveolar echinococcosis , serology , medicine , pathology , china , echinococcosis , ultrasound , radiology , immunology , geography , antibody , archaeology
Summary We correlated ultrasound (US) imaging classifications for human alveolar echinococcosis (AE) and cystic echinococcosis (CE) with serology (ELISA and immunoblotting (IB) incorporating native and recombinant/purified echinococcal antigens) in community surveys (2001–2003) and follow‐up (2002 and 2003) of US‐confirmed cases in Ningxia, China. One hundred and seventy‐one cases (96 with AE, 75 with CE) were identified; of these, US classification and serological data were obtained for 142 and 112 cases, respectively. Seropositive‐rates increased in CE patients with highly viable unilocular cyst lesions (Types CL, CE 1 or CE 2) to degenerating primary lesions (CE 3), but then decreased in subjects with inactive (CE 4) or dead (CE 5) cysts. In contrast, there was a constant increase in seropositivity from the early (P1, P2) to the advanced stages (P3, P4) with AE cases. For US‐confirmed cases, follow‐up by US combined with serology is invaluable for studying the clinical progression of echinococcosis and for detecting recurrent cysts or reinfection post‐treatment.