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Evaluación del tamizaje en grupos (pooled screening) para anti‐VHC en dos bancos de sangre
Author(s) -
Novack Lena,
Shinar Eilat,
Safi Jamal,
Soliman Hassan,
Yaari Arieh,
Galai Noya,
Pliskin Joseph S.,
Sarov Batia
Publication year - 2007
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2006.01810.x
Subject(s) - medicine , pooling , blood bank , blood donor , blood donations , virology , emergency medicine , immunology , artificial intelligence , computer science
Summary Objective Screening blood donations for anti‐HCV is only partially performed in many developing countries due to the relatively high costs of testing. The screening expenditures can be reduced by testing donations in pools. This study evaluates the accuracy and feasibility of pooled screening procedure for anti‐HCV in blood banks in Israel and the Palestinian Authority. Methods The sensitivity and specificity of tests performed on pool sizes of 6–24 samples were compared to singleton immunoassay testing. All negative samples and those positive for anti‐HCV were obtained from the routine work of Magen David Adom Blood Services in Israel and Shifa Hospital blood bank in Palestinian Authority. The experiments were run in parallel with different technologies. Results The sensitivity of pooled‐testing for anti‐HCV by Magen David Adom was 94–97% for verified samples. In the Shifa Hospital, the sensitivity was estimated as 96–97% for non‐verified samples. Cost‐analysis showed benefits up to $2 per donation screened for anti‐HCV in Shifa Hospital. Conclusions We recommend using manually created pools of up to 6 samples when testing for anti‐HCV, but at the cost of 3% loss in sensitivity. Pooling can be considered, in countries which do not perform routine screening, due to their limited economic resources.