z-logo
Premium
Prevalencia de microorganismos Gram‐negativos multiresistentes en un hospital quirúrgico en la Ciudad Ho Chi Minh, Vietnam
Author(s) -
Jones S. L.,
Nguyen V. K.,
Nguyen T. M. P.,
Athan E.
Publication year - 2006
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2006.01731.x
Subject(s) - medicine , antibiotics , ciprofloxacin , cefotaxime , ceftazidime , antibiotic resistance , gentamicin , ceftriaxone , infection control , microbiology and biotechnology , ho chi minh , cephalosporin , biology , intensive care medicine , bacteria , pseudomonas aeruginosa , geography , genetics , cartography , scale (ratio)
Summary Objective  To determine resistance patterns of multiresistant Gram‐negative organisms at a surgical hospital in Ho Chi Minh City, Vietnam, in order to guide appropriate antibiotic prescribing and improve infection control procedures. Method  All samples sent in for microbiological analysis over a 3‐month period were included. A resource neutral double disc‐diffusion test was introduced to detect the presence of extended‐spectrum β ‐lactamase (ESBL) production. Results  We obtained 350 bacterial isolates from clinical specimens; 87.4% were Gram‐negative bacteria (GNB). Of these, 88.9% were Enterobacteriaceae, of which 14.7% produced ESBL. Fifteen (37.5%) of these were isolated within 48 h of admission. Resistance to gentamicin and ciprofloxacin occurred in 70.0% and 72.5% of those organisms that produced ESBL and in 39.5% and 38.7% of those that did not. Resistance to third‐generation cephalosporins was common: 36.7% of all GNB were resistant to ceftriaxone, 34.0% to cefotaxime, 19.6% to ceftazidime and 36.7% to cefoperazone. Conclusion  Multiresistant Gram‐negative organisms are common and pose a challenge to antibiotic therapy. Successful implementation of a simple test to detect ESBL production allowed reporting of these organisms, appropriate antibiotic prescribing and infection control interventions. Development of antibiotic‐prescribing guidelines must take into account these resistance patterns.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here