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Prevalencia de microorganismos Gram‐negativos multiresistentes en un hospital quirúrgico en la Ciudad Ho Chi Minh, Vietnam
Author(s) -
Jones S. L.,
Nguyen V. K.,
Nguyen T. M. P.,
Athan E.
Publication year - 2006
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2006.01731.x
Subject(s) - medicine , antibiotics , ciprofloxacin , cefotaxime , ceftazidime , antibiotic resistance , gentamicin , ceftriaxone , infection control , microbiology and biotechnology , ho chi minh , cephalosporin , biology , intensive care medicine , bacteria , pseudomonas aeruginosa , geography , genetics , cartography , scale (ratio)
Summary Objective To determine resistance patterns of multiresistant Gram‐negative organisms at a surgical hospital in Ho Chi Minh City, Vietnam, in order to guide appropriate antibiotic prescribing and improve infection control procedures. Method All samples sent in for microbiological analysis over a 3‐month period were included. A resource neutral double disc‐diffusion test was introduced to detect the presence of extended‐spectrum β ‐lactamase (ESBL) production. Results We obtained 350 bacterial isolates from clinical specimens; 87.4% were Gram‐negative bacteria (GNB). Of these, 88.9% were Enterobacteriaceae, of which 14.7% produced ESBL. Fifteen (37.5%) of these were isolated within 48 h of admission. Resistance to gentamicin and ciprofloxacin occurred in 70.0% and 72.5% of those organisms that produced ESBL and in 39.5% and 38.7% of those that did not. Resistance to third‐generation cephalosporins was common: 36.7% of all GNB were resistant to ceftriaxone, 34.0% to cefotaxime, 19.6% to ceftazidime and 36.7% to cefoperazone. Conclusion Multiresistant Gram‐negative organisms are common and pose a challenge to antibiotic therapy. Successful implementation of a simple test to detect ESBL production allowed reporting of these organisms, appropriate antibiotic prescribing and infection control interventions. Development of antibiotic‐prescribing guidelines must take into account these resistance patterns.