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Hormonas hipofisarias y gonadales y patrones de interleukina en lepra
Author(s) -
Leal Ângela M. O.,
Magalhães Patrícia K. R.,
Souza Cacilda S.,
Foss Norma T.
Publication year - 2006
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2006.01692.x
Subject(s) - medicine , endocrinology , luteinizing hormone , testosterone (patch) , prolactin , hormone , follicle stimulating hormone , erythrocyte sedimentation rate , interleukin , gonadotropin , cytokine
Summary The functional status of pituitary–gonadal hormones and their relationship to the pattern of inflammatory cytokines in the lepromatous (LL/BL) and tuberculoid (TT/BT) poles of leprosy were investigated. Gonadotropins [luteinizing hormone (LH) and follicle‐stimulating hormone (FSH)], interleukin (IL)‐1 β , IL‐6, tumour necrosis factor (TNF)‐ α and C‐reactive protein (CRP) concentrations and erythrocyte sedimentation rate (ESR) were significantly higher in LL/BL leprosy patients than in controls and were not different from controls in TT/BT patients. LH and FSH were positively correlated with IL‐1 β , IL‐6 and TNF‐ α , and CRP concentrations and ESR. Testosterone plasma levels were significantly decreased in LL/BL patients and not different in TT/BT patients compared with controls. In addition, testosterone levels were inversely correlated with IL‐6 and TNF‐ α . Prolactin plasma levels of both LL/BL and TT/BT patients were not different when compared with those of controls. There was a significant positive correlation between IL‐6 and TNF‐ α plasma levels and ESR and CRP concentrations. IL‐1 β was positively correlated with ESR but not with CRP. The significant correlations between gonadotropins and testosterone and cytokines in leprosy patients suggest that cytokines may have a direct influence at testicular level and may be of pathogenetic significance in leprosy and in other inflammatory states involving reproductive dysfunction.