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Multiple genotypes of the merozoite surface proteins 1 and 2 in Plasmodium falciparum infections in a hypoendemic area in Iran
Author(s) -
Zakeri Sedigheh,
Bereczky Sándor,
Naimi Parin,
Pedro Gil J.,
Djadid Navid Dinparast,
Färnert Anna,
Snounou Georges,
Björkman Anders
Publication year - 2005
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.2005.01477.x
Subject(s) - plasmodium falciparum , merozoite surface protein , genotype , genetic diversity , malaria , biology , transmission (telecommunications) , plasmodium vivax , virology , medicine , immunology , population , genetics , gene , malaria vaccine , environmental health , electrical engineering , engineering
Summary In Iran, malaria transmission mainly occurs in south‐eastern regions through both Plasmodium falciparum and P. vivax . The genetic diversity of P. falciparum isolates was analysed in 108 patients attending the regional hospital in Chabahar District, using the molecular markers msp1 and msp2 . Multiple genotypes were detected in 87% of patients and the mean numbers of msp1 and msp2 genotypes were 2.51 (95% CI: 2.29–2.73) and 2.61 (95% CI: 2.39–2.83) respectively. Various allelic types of msp1 and msp2 were found, with msp2 3D7/IC type detected in 94% of infections. Plasmodium falciparum infections in south‐east Iran appear to have a higher genetic diversity than expected for an area of low transmission. A situation of higher transmission in this area may be emerging, possibly because of reduced efficacy of first‐line treatments.