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Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi
Author(s) -
Zuñiga Claudio,
Palau Teresa,
Penin Pilar,
Gamallo Carlos,
Diego Jose Antonio
Publication year - 1997
Publication title -
tropical medicine and international health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.056
H-Index - 114
eISSN - 1365-3156
pISSN - 1360-2276
DOI - 10.1111/j.1365-3156.1997.tb00171.x
Subject(s) - trypanosoma cruzi , biology , virulence , inoculation , histopathology , microbiology and biotechnology , chagas disease , infectivity , virology , kinetoplastida , amastigote , protozoa , parasite hosting , immunology , medicine , virus , gene , pathology , leishmania , biochemistry , world wide web , computer science
Summary We investigated the protective effect of Trypanosoma rangeli against infection with Trypanosoma cruzi in animal models of various ages and with different doses of inoculum. The age of the mice and the dose of parasites determined the course of the infection. When T. cruzi was inoculated into mice after challenge with T. rangeli , parasitaemia was more controlled, mortality decreased and histopathology showed lower inflammatory infiltration and pseudocysts. This study proposes a new murine model of the protective effect of recombinant proteins of T. rangeli for possible application in the vaccines field.