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Platelet‐specific alloantigens and antibodies in Tunisian women after three or more pregnancies
Author(s) -
Skouri H.,
Gandouz R.,
Kraiem I.,
Dridi H.,
Bibi M.,
Khairi H.,
Jemmali M.,
Bierling P.
Publication year - 2009
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2009.00940.x
Subject(s) - neonatal alloimmune thrombocytopenia , antibody , platelet , immunology , antigen , isoantibodies , pregnancy , medicine , monoclonal antibody , clinical significance , fetus , biology , genetics
summary . Pregnancy may allow alloimmunization against human platelet antigens (HPA), which can lead to neonatal alloimmune thrombocytopenia (NAIT). The specificities of alloantibodies are closely related to the distribution of the HPA systems. A total of 281 Tunisian multiparous women (mean number of pregnancies: 4.5) were phenotyped for the HPA‐1, ‐3 and ‐5 systems, by monoclonal antibody immobilization of platelet antigens (MAIPA). We searched for antibodies against HPA‐1a, HPA‐3a, HPA‐5b and HPA‐5a in HPA‐1b1b, HPA‐3b3b, HPA‐5a5a and HPA‐5b5b individuals, respectively. The gene frequencies were: 0·83 for HPA‐1a, 0·17 for HPA‐1b, 0·78 for HPA‐3a, 0·22 for HPA‐3b, 0·82 for HPA‐5a and 0·18 for HPA‐5b. Anti‐HPA‐5b antibodies were present in eight sera and anti‐HPA‐3a antibodies were present in one serum. The anti‐HPA‐5b system is the most frequently involved in platelet alloimmunization in Tunisian multiparous women. However, prospective trials are required to confirm this result and to determine the exact frequencies and clinical relevance of platelet alloantibodies in pregnant Tunisian women.