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Respiratory complications after haematopoietic stem cell transplantation in a patient with chronic granulomatous disease
Author(s) -
Hara K.,
Kajiume T.,
Kondo T.,
Sera Y.,
Kawaguchi H.,
Kobayashi M.
Publication year - 2009
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2009.00909.x
Subject(s) - chronic granulomatous disease , medicine , severe combined immunodeficiency , hematopoietic stem cell transplantation , haematopoiesis , disease , bone marrow transplantation , immunodeficiency , stem cell , immunology , genetic enhancement , respiratory disease , bone marrow , respiratory system , transplantation , pathology , lung , surgery , immune system , biology , gene , biochemistry , genetics
summary Chronic granulomatous disease (CGD) is an inherited immunodeficiency disorder caused by defects in NADPH oxidase and characterized by recurrent life‐threatening bacterial and fungal infections. Although CGD has been considered to be a target for gene therapy, bone marrow transplantation (BMT) is now selected as the radical treatment in most cases. We performed BMT in a patient with CGD with severe infections and experienced respiratory complications of diffuse alveolar haemorrhage and/or infection‐associated alveolar haemorrhage. We suggest that attention be paid to signs of onset of alveolar haemorrhage during BMT in CGD patients.