Premium
The evidence for the use of recombinant factor VIIa in massive bleeding: development of a transfusion policy framework
Author(s) -
Moltzan C. J.,
Anderson D. A.,
Callum J.,
Fremes S.,
Hume H.,
Mazer C. D.,
Poon M. C.,
Rivard G.,
Rizoli S.,
Robinson S.
Publication year - 2008
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2008.00846.x
Subject(s) - recombinant factor viia , haemophilia , medicine , factor viia , randomized controlled trial , intensive care medicine , clotting factor , coagulation , blood transfusion , surgery , tissue factor
summary A review of the recent randomized control trial evidence of the use of recombinant factor VIIa (rFVIIa) in massive bleeding. rFVIIa is a recombinant genetically engineered clotting factor that has been used for the management of haemophilia patients with inhibitors. There has been increasing use in patients with massive bleeding, even when there is no underlying coagulation disorder present. In November 2006, the Canadian National Advisory Committee on Blood and Blood Products engaged in a consultation and review process with several leading Canadian experts to review and discuss the current evidence up to November 2006. There is little evidence to support the routine use of rFVIIa in massive bleeding on review of 13 randomized controlled trials. rFVIIa should only be considered as part of a transfusion policy framework for massive bleeding after all other transfusion and supportive measures are considered. An example of a policy framework is presented.