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Repeat ABO‐incompatible platelet transfusions leading to haemolytic transfusion reaction
Author(s) -
Sadani D. T.,
Urbaniak S. J.,
Bruce M.,
Tighe J. E.
Publication year - 2006
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2006.00684.x
Subject(s) - abo blood group system , apheresis , medicine , titer , isoantibodies , haemolytic disease , platelet , transfusion medicine , group b , abo incompatibility , platelet transfusion , immunology , antibody , blood transfusion , pregnancy , biology , fetus , genetics
summary A 65‐year‐old woman, blood group A RhD positive, who had completed her first course of induction chemotherapy for acute myeloid leukaemia was transfused with apheresis platelets over a number of days. On three occasions she received group O RhD positive units, which had been screened and found not to contain high‐titre anti‐A,B isoagglutinins. Following the third unit, she developed a haemolytic transfusion reaction and died soon thereafter. This has led to change in policy of the supplying centre in testing for high‐titre anti‐A,B isoagglutinins. Blood group O apheresis platelets and fresh‐frozen plasma units are now labelled as high titre with a cut‐off of 1/50 as compared to the previous cut‐off of 1/100 for anti‐A,B isoagglutinins. A universal approach to testing donations for high‐titre anti‐A,B isoagglutinins, better compliance of guidelines and monitoring of patients is necessary.