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Heterogeneity of cytokine single‐nucleotide polymorphisms among the Iranian and in the other East‐South Asian populations
Author(s) -
Bagheri M.,
AbdiRad I.,
Omrani D.,
Khalkhali H. R.
Publication year - 2006
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2006.00666.x
Subject(s) - single nucleotide polymorphism , genotype , biology , genetics , allele , cytokine , microbiology and biotechnology , typing , gene , polymerase chain reaction
summary . Cytokine gene polymorphisms may affect their transcription, influence their level of production and may be implicated in inducing susceptibility or resistance to diseases. In 40 Iranian healthy subjects, cytokine single‐nucleotide polymorphisms (SNPs) were used to determine allelic and genotypic frequencies for the following cytokine genes: IL‐1a (T/C −889), IL‐1β (C/T −511, T/C 3962), IL‐12 (C/A −1188), IFN‐γ (A/T UTR 5644), TGF‐β (C/T codon 10, G/C codon 25), TNF‐a (G/A −308, G/A −238), IL‐2 (T/G −330, G/T 166), IL‐4 (T/G −1089, T/C −590, T/C −33), IL‐6 (G/C −174, G/A nt565), IL‐10 (G/A −1082, C/T −819, C/A −592), IL‐1R (C/T pst11970), IL‐1RA (T/C mspa111100) and IL‐4RA (G/A 1902). All typing were performed with polymerase chain reaction with sequence specific primers assay. Significant heterogeneity of cytokine SNPs among the Iranian and the other East‐South Asian populations was observed. Heterogeneity of cytokine SNPs may explain the role of natural selection in susceptibilities of populations to different disorders.