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Febrile nonhaemolytic transfusion reaction caused by antibodies against human platelet antigen 5a
Author(s) -
Tazzari P. L.,
Bontadini A.,
Zamagni C.,
Ricci F.,
Fruet F.,
Iannelli S.,
Conte R.
Publication year - 2005
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2005.00602.x
Subject(s) - antibody , platelet , transfusion reaction , immunology , medicine , platelet transfusion , antigen , blood transfusion
summary . Anti‐human platelet antigens (HPA) alloantibodies are seldom involved in febrile nonhaemolytic reactions (FNHTRs). We describe a case in which anti‐HPA‐5a alloantibodies are related to an FNHTR. We studied the specificity of the alloantibodies by flow cytometry, ELISA and MACE. Typing of donors and the patient was performed by sequence‐specific polymerase chain reaction. The alloantibodies were found reactive with HPA‐5a antigens. The patient was HPA‐5b/b, whereas the donor of the platelet apheresis involved in the FNHTR was HPA‐5a/a. Despite the low frequency of anti‐HPA‐5a antibodies, they might be responsible for FNHTR.