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Neonatal alloimmune thrombocytopenia due to an antibody against a labile component of human platelet antigen‐3b (Bak b )
Author(s) -
Kataoka S.,
Kobayashi H.,
Chiba K.,
Nakamura M.,
Shinada S.,
Morita S.,
Lin M.,
Shibata Y.
Publication year - 2004
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2004.00537.x
Subject(s) - platelet , antigen , antibody , neonatal alloimmune thrombocytopenia , immunofluorescence , hemagglutination , immunology , monoclonal antibody , microbiology and biotechnology , chemistry , medicine , biology , fetus , pregnancy , genetics
Summary. We report the second case of neonatal alloimmune thrombocytopenia due to anti‐human platelet antigen (HPA)‐3b (Bak b ) antibody. The infant was severely affected with intracranial haemorrhage. Most importantly, we were able to detect this antibody only by using fresh, unfixed platelets as antigen. This antibody was detectable neither by conventional mixed passive haemagglutination, platelet immunofluorescence test using fixed platelets, nor by monoclonal antigen immobilization of platelet antigen assay using solubilized platelets. We assume that this antibody reacts only with fresh platelets and that the antigen is a labile component of HPA‐3b (Bak b ).