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Platelet alloantigens HPA‐1, ‐2, ‐3, ‐5 and ‐6b in Finns
Author(s) -
Kekomäki S.,
Partanen J.,
Kekomäki R.
Publication year - 1995
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.1995.tb00227.x
Subject(s) - allele , allele frequency , immunology , antigen , platelet , monoclonal antibody , population , antibody , biology , european population , medicine , gene , genetics , environmental health
SUMMARY. The human platelet alloantigens HPA‐1, ‐2, ‐3, ‐5 and ‐6b in the Finnish population were determined using allele specific restriction analysis (PCR‐ASRA) for HPA‐1, ‐2, ‐3 and ‐5 and monoclonal antibody immobilized platelet antigen (MAIPA) assay for HPA‐1, ‐3a, ‐5b and ‐6b. No discrepancies were observed between the results obtained with the PCR‐method and those obtained serologically. The gene frequencies obtained from 200 unrelated Finns were 0.86 and 0.14 for HPA‐1a and ‐1b, 0.91 and 0.09 for HPA‐2a and ‐2b, 0.59 and 0.41 for HPA.3a and ‐3b and 0.95 and 0.05 for HPA‐5a and ‐5b. The frequency of the HPA‐5b allele (10%) is lower in Finns than in Central‐ or South‐European populations (20–30%). The HPA‐1, ‐2 and ‐3 frequencies did not deviate from those observed in other European populations. The rare HPA‐6b antigen was observed in three of 127 individuals from south‐eastern Finland (2.4%), which suggests that the frequency of this allele in Finland is higher than previously thought.