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Rapid detection of Rh(D)‐ or K‐positive fetal red cells in chorion villus samples by a flow cytometric technique
Author(s) -
Nelson M.,
Forsyth C.,
Popp H.,
Gibson J.
Publication year - 1994
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.1994.tb00267.x
Subject(s) - fetus , rh isoimmunization , andrology , obstetrics , pregnancy , medicine , second trimester , gynecology , biology , genetics
SUMMARY. Rh(D)‐ and K‐negative women who have become severely isoimmunized by pregnancy are at risk of fetal loss or damage in subsequent pregnancies. A flow cytometric method is described whereby the presence of Rh(D) or K antigen on fetal erythrocytes may be determined using chorion villus samples taken during the first trimester. This method has the advantage of speed and sensitivity with results being available within 2h. Decisions as to management of the pregnancy or termination may thus be made with minimal delay.