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Guidelines for the collection, processing and storage of human bone marrow and peripheral stem cells for transplantation
Author(s) -
Voak D.,
Cann R.,
Finney R. D.,
Foreman K.,
Knowles S. M.,
Mitchell R.,
Napier J. A. F.,
Phillips P. K.,
Rejman A. J.,
Waters A. H.,
Wood J. K.,
Hutchinson R. M.,
Bell A. J.,
Duguid J. K. M.,
Hows J. M.,
Jestice K.,
Pegg D. E.,
Testa N. G.
Publication year - 1994
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.1994.tb00258.x
Subject(s) - medicine , stem cell , bone marrow , umbilical cord , peripheral blood , peripheral blood stem cells , transplantation , bone marrow transplantation , immunology , hematopoietic stem cell transplantation , surgery , biology , genetics
SUMMARY. There are no current U.K. or international guidelines or regulations covering the production, processing and storage of haemopoietic cells such as to allow their engraftment following myeloablative therapy. This paper seeks to provide such guidelines. It enumerates how quality control and assurance can be applied to this area of transfusion medicine; procedural steps relating to bone marrow harvest on peripheral blood stem cell collection are outlined and recommended doses of nucleated cells suggested for both procedures. General specifications for identification, storage and transportation of bone marrow and peripheral blood stem cells are included and specific laboratory procedures related to the provision of haemopoietic cells for engraftment are outlined. Umbilical cord blood transplants and long‐term bone marrow culture are alluded to but these are still in a research phase.