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ERIK, a low‐frequency red cell antigen of the MNS blood group system associated with Sta
Author(s) -
Daniels G. L.,
Green C. A.,
Poole J.,
Jerne D.,
Smart E.,
Wilcox D.,
Young S.
Publication year - 1993
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.1993.tb00050.x
Subject(s) - glycophorin , antigen , microbiology and biotechnology , epitope , trypsin , antibody , red blood cell , red cell , gene , biology , chemistry , genetics , immunology , medicine , biochemistry , enzyme
Summary. A new low‐frequency red cell antigen, ERIK (MNS37), is associated with the St a antigen of the MNS system. Four ERIK + propositi have been identified: all are St(a+). Thirteen other St(a+) samples, including one of the M z type, and over 200 St(a‐) samples were ERIK‐. In two of the propositi ERIK is associated with an abnormal trypsin‐resistant M antigen; in the others it is associated with N, which is shown to be expressed weakly in one family. Immunoblotting with an antibody to an epitope common to glycophorin A (GPA) and glycophorin B (GPB) gave identical results with St(a+) EiRIK + and St(a+) ERIK‐cells, revealing GPA, GPB, an abnormal structure GPSt a aggregates of these components. In the propositi with trypsin‐resistant M, GPSt a carries the unusual M antigen, whereas in the M ‐ N + ERIK+ individual analysed by immunoblotting GPSt a carries N. Immunoblotting with anti‐St a anti‐ERIK showed that St a is located on GPSt a but that ERIK is located on GPA, presumably the GPA molecule encoded by the GYPA gene contiguous to the gene encoding GPSt a .