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HDA19 is required for the repression of salicylic acid biosynthesis and salicylic acid‐mediated defense responses in Arabidopsis
Author(s) -
Choi SunMee,
Song HaeRyong,
Han SoonKi,
Han Muho,
Kim ChiYeol,
Park Jaejin,
Lee YongHwan,
Jeon JongSeong,
Noh YooSun,
Noh Bosl
Publication year - 2012
Publication title -
the plant journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.058
H-Index - 269
eISSN - 1365-313X
pISSN - 0960-7412
DOI - 10.1111/j.1365-313x.2012.04977.x
Subject(s) - psychological repression , pseudomonas syringae , salicylic acid , arabidopsis , chromatin , biology , histone , plant defense against herbivory , microbiology and biotechnology , reprogramming , chromatin immunoprecipitation , histone deacetylase , genetics , gene , gene expression , promoter , mutant
Summary To cope with a lifetime of exposure to a variety of pathogens, plants have developed exquisite and refined defense mechanisms that vary depending on the type of attacking pathogen. Defense‐associated transcriptional reprogramming is a central part of plant defense mechanisms. Chromatin modification has recently been shown to be another layer of regulation for plant defense mechanisms. Here, we show that the RPD3/HDA1‐class histone deacetylase HDA19 is involved in the repression of salicylic acid (SA)‐mediated defense responses in Arabidopsis. Loss of HDA19 activity increased SA content and increased the expression of a group of genes required for accumulation of SA as well as pathogenesis related ( PR ) genes, resulting in enhanced resistance to Pseudomonas syringae . We found that HDA19 directly associates with and deacetylates histones at the PR1 and PR2 promoters. Thus, our study shows that HDA19, by modifying chromatin to a repressive state, ensures low basal expression of defense genes, such as PR1 , under unchallenged conditions, as well as their proper induction without overstimulation during defense responses to pathogen attacks. Thus, the role of HDA19 might be critical in preventing unnecessary activation and self‐destructive overstimulation of defense responses, allowing successful growth and development.