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Potential Implication of Activating Killer Cell Immunoglobulin‐Like Receptor and HLA in Onset of Pulmonary Tuberculosis
Author(s) -
Lu C.,
Bai X. L.,
Shen Y. J.,
Deng Y. F.,
Wang C. Y.,
Fan G.,
Chu J. X.,
Zhao S. M.,
Zhang B. C.,
Zhao Y. R.,
Zhang C. Z.,
Ye H.,
Lu Z. M.
Publication year - 2012
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2012.02762.x
Subject(s) - genotyping , human leukocyte antigen , genotype , immunology , immune system , allele , antibody , polymerase chain reaction , biology , gene , allele frequency , haplotype , antigen , genetics
Killer cell immunoglobulin‐like receptor (KIR) and human leucocyte antigen (HLA) play crucial role in maintaining immune homoeostasis and controlling immune responses. To investigate the influence of KIR and HLA‐C ligands on the risk of pulmonary tuberculosis (PTB), we studied 200 patients who were confirmed to have PTB and 200 healthy controls on the different frequencies of KIR and HLA‐C ligands. Genotyping of these genes was conducted by sequence‐specific primer polymerase chain reaction (SSP‐PCR) method. Gene frequencies were compared between PTB group and the control group by χ 2 test, and P < 0.05 was regarded as statistically significant. As a result, the frequency of KIR genotype A/B was increased in PTB than controls but A/A was decreased. Moreover, striking differences were observed in the frequencies of HLA‐Cw*08 between the two groups. Besides, the frequencies of ‘2DL2/3 with C1’ in PTB were increased compared with control group. In addition, individuals with no KIR2DS3 and no Cw*08 were higher in controls than in PTB. KIR2DS1 was increased in PTB when HLA‐C group 2 alleles were missing. In conclusion, KIR and HLA‐C gene polymorphisms were related to susceptibility to PTB.