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Protective Effect of HLA‐DRB1*11 and Predisposition of HLA‐C*04 in the Development of Severe Liver Damage in Brazilian Patients with Chronic Hepatitis C Virus Infection
Author(s) -
Marangon A. V.,
Silva G. F.,
de Moraes C. F. V.,
Grotto R. M. T.,
Pardini M. I. M. C.,
de Pauli D. S.,
Visentainer J. E. L.,
Sell A. M.,
Moliterno R. A.
Publication year - 2012
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2012.02755.x
Subject(s) - human leukocyte antigen , hepatitis c virus , genotype , haplotype , medicine , immunology , virus , hla drb1 , chronic hepatitis , liver damage , typing , allele , hepatitis c , antigen , gene , biology , genetics
The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty‐five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A*, B*, C*) and class II (DRB1*, DQA1*, DQB1*) typing were carried out by PCR‐SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1*11 (5.0% versus 18.2%, P = 0.0016, OR = 0.23, CI 95% = 0.09–0.58; Pc =0.0208) and DRB1*11‐DQA1*05‐DQB1*03 haplotype (4.2% versus 15.3%, P = 0.0032; OR = 0.24, CI 95% = 0.08‐0.64). Liver damage was associated with HLA‐C*04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95% = 1.97–19.7; Pc =0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type‐1 chronically infected Brazilian patients.