Premium
Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis
Author(s) -
FreitasTeixeira P. M.,
SilveiraLemos D.,
Giunchetti R. C.,
BarattaMasini A.,
Mayrink W.,
PeruhypeMagalhães V.,
Rocha R. D. R.,
CampiAzevedo A. C.,
TeixeiraCarvalho A.,
MartinsFilho O. A.
Publication year - 2012
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2012.02748.x
Subject(s) - immunology , cd23 , cd8 , biology , acquired immune system , leishmania , cd5 , immunity , cutaneous leishmaniasis , immunophenotyping , leishmania major , leishmaniasis , immune system , antibody , antigen , immunoglobulin e , parasite hosting , world wide web , computer science
In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT − ;MT + ). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR + neutrophils; ↑CD8 + HLA‐DR + /CD4 + HLA‐DR + T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23 + neutrophils, monocytes and B cells; ↑α‐ Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR + neutrophils, ↑CD8 + HLA‐DR + /CD4 + HLA‐DR + T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5 − B cells; ↑CD23 + B cells and ↑α‐ Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28 + neutrophils and ↑%CD4 + T cells), >60 showed a well‐known leishmanicidal events (↑CD8 + T cells; ↑serum + and ↑α‐ Leishmania IgG). MT + patients showed increased putative leishmanicidal capacity (↑%HLA‐DR + neutrophils; ↑%CD23 + monocytes; ↑CD8 + HLA‐DR + /CD4 + HLA‐DR + T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.