Premium
Direct and Indirect Regulatory Mechanisms in TH17 cell Differentiation and Functions
Author(s) -
Bi Y.,
Yang R.
Publication year - 2012
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2012.02686.x
Subject(s) - immune system , function (biology) , immunology , biology , regulatory t cell , mechanism (biology) , cellular differentiation , autoimmunity , microbiology and biotechnology , t cell , genetics , gene , il 2 receptor , philosophy , epistemology
T helper 17 (TH17) cells have well‐described roles in autoimmune diseases. The immune modulations of development and function of TH17 have become a key issue. In this review, we summarize the recent findings regarding the direct and indirect signalling regulatory mechanisms of TH17 cells in the general mouse model of autoimmune diseases and other human diseases.