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Production of Interleukin‐13 is Influenced by the Interleukin‐4 −34TT and −590TT Genotype in Patients with Aggressive Periodontitis
Author(s) -
Gonzales J. R.,
Gröger S.,
Haley G.,
Bödeker R.H.,
Meyle J.
Publication year - 2011
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2010.02482.x
Subject(s) - genotype , aggressive periodontitis , periodontitis , interleukin , allele , immunology , biology , medicine , cytokine , gene , genetics
Aggressive periodontitis (AgP) is a specific form of periodontal disease, with rapid destruction of the tissues supporting the teeth in otherwise young healthy individuals. We recently showed a higher frequency of the interleukin‐4 (IL‐4) −34TT and −590TT genotype in AgP patients compared to controls ( P < 0.05). Herein, we demonstrated that this specific IL‐4 genotype exerts its function by increasing expression of IL‐4 and STAT6, and producing higher concentrations of IL‐4 in activated CD4+ cells of patients with AgP. In the present study, we investigated the effects of the IL‐4‐specific genotype on IL‐13, IL‐2 and IFN‐γ expression and production in activated CD4+ cells of patients with AgP and healthy controls. Results revealed higher IFN‐γ and IL‐2 expression and significantly increased IL‐13 production in the cells of the patients who were homozygous for the −34T and −590T alleles in comparison with the patients who were homozygous for the −34C and −590C alleles ( P < 0.05). Results of controls with the −34C and −590C alleles were similar to those of AgP with the same genotype. To our knowledge, the present study is the first to show an effect of the −34TT and −590TT genotype on IL‐13 production. There is an increased production of IL‐13 by the T cells of aggressive periodontitis patients with the IL‐4 genotype.