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MHC II and the Endocytic Pathway: Regulation by Invariant Chain
Author(s) -
Landsverk O. J. B.,
Bakke O.,
Gregers T. F.
Publication year - 2009
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2009.02301.x
Subject(s) - mhc restriction , cd74 , major histocompatibility complex , endosome , mhc class i , microbiology and biotechnology , t cell receptor , mhc class ii , biology , antigen processing , cd8 , endocytic cycle , transporter associated with antigen processing , acquired immune system , antigen presentation , immune system , t cell , immunology , receptor , endocytosis , biochemistry , intracellular
The major histocompatibility complex (MHC) class I and II molecules perform vital functions in innate and adaptive immune responses towards invading pathogens. MHC class I molecules load peptides in the endoplasmatic reticulum (ER) and display them to the T cell receptors (TcR) on CD8 + T lymphocytes. MHC class II molecules (MHC II) acquire their peptides in endosomes and present these to the TcR on CD4+ T lymphocytes. They are vital for the generation of humoral immune responses. MHC II assembly in the ER and trafficking to endosomes is guided by a specialized MHC II chaperone termed the invariant chain (Ii). Ii self‐associates into a trimer in the ER, this provides a scaffold for the assembly of three MHC II heterodimers and blocks their peptide binding grooves, thereby avoiding premature peptide binding. Ii then transports the nascent MHC II to more or less specialized compartment where they can load peptides derived from internalized pathogens.