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The Role of Granulocyte Macrophage‐Colony Stimulating Factor in Gastrointestinal Immunity to Salmonellosis
Author(s) -
Coon C.,
Beagley K. W.,
Bao S.
Publication year - 2009
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2009.02279.x
Subject(s) - immune system , typhoid fever , immunology , biology , immunity , salmonella , tumor necrosis factor alpha , cytokine , macrophage , granulocyte macrophage colony stimulating factor , granulocyte , pathogenesis , inflammation , microbiology and biotechnology , innate immune system , bacteria , in vitro , biochemistry , genetics
Human Salmonella infection, in particular, typhoid fever is a highly infectious disease that remains a major public health problem causing significant morbidity and mortality. The outcome of these infections depends on the host’s immune response, particularly the actions of granulocytes and macrophages. Using a mouse model of human typhoid fever, with Salmonella typhimurium infection of wild type and granulocyte macrophage‐colony stimulating factor (GM‐CSF) knock out mice we show a delay in the onset of immune‐mediated tissue damage in the spleens and livers of GM‐CSF −/− mice. Furthermore, GM‐CSF −/− mice have a prolonged sequestration of S. typhimurium in affected tissues despite an increased production of F4/80 + effector cells. Moreover in the absence of GM‐CSF, a decrease in pro‐inflammatory cytokine expression of tumor necrosis factor‐α, interleukin‐12 (IL‐12) and IL‐18 was found, which may alter the host’s immune response to infection. GM‐CSF appears to play an important role in the pathogenesis of Salmonellosis , and may contribute significantly to the development of protective gastrointestinal mucosal immune responses against oral pathogens.