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On the Critique by Colin Anderson of ‘A Reply to Dembic: On an End to the Beginning of Mis‐Understanding the Immune Response’
Author(s) -
Cohn M.
Publication year - 2009
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2009.02264.x
Subject(s) - repertoire , mechanism (biology) , set (abstract data type) , criticism , epistemology , cognitive science , sorting , psychology , computer science , sociology , philosophy , law , political science , algorithm , literature , programming language , art
Abstract My proposal of a set of postulates that can be used to guide computer modeling has understandably met with significant criticism at two levels, semantic and conceptual. The major source of contention is my assumption that the sorting of the paratopic repertoire is both necessary and sufficient to explain the evolutionarily selected mechanism for the self‐nonself discrimination. While `necessary' is agreed upon, `sufficient' is debatable as this commentary illustrates. My essay is in defense of `sufficiency'.