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Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection
Author(s) -
Venturini J.,
De Camargo M. R.,
Félix M. C.,
VilaniMoreno F. R.,
De Arruda M. S. P.
Publication year - 2009
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2009.02260.x
Subject(s) - candida albicans , macrophage , corpus albicans , microbiology and biotechnology , hydrogen peroxide , nitric oxide , biology , tumor necrosis factor alpha , chemistry , immunology , biochemistry , in vitro , endocrinology
To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H 2 O 2 ) , nitric oxide and TNF‐α production by peritoneal macrophages from Ehrlich tumour‐bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H 2 O 2, TNF‐α levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H 2 O 2 and TNF‐α that was paired with the dissemination of C. albicans . These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host’s susceptibility to opportunistic infections.