Premium
Expression of Mast Cell Tryptases in Hodgkin and Reed‐Sternberg (HRS) Cells
Author(s) -
Carvalho Ricardo F. S.,
Mahshid Yilmaz,
Claesson HansErik,
Glimelius Ingrid,
Fischer Marie,
Nilsson Gunnar
Publication year - 2008
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2007.02033.x
Subject(s) - tryptase , reed–sternberg cell , mast cell , lymphoma , hodgkin lymphoma , non hodgkin's lymphoma , biology , in vitro , pathology , microbiology and biotechnology , cancer research , immunology , medicine , biochemistry
Tryptase is the most abundant protease in human mast cells, and is often used as a marker for the enumeration of mast cells in tissue. Here we report that tumour cells from Hodgkin lymphoma, the so called Hodgkin and Reed‐Sternberg cells, can express tryptase. Hodgkin lymphoma cell lines expressed mRNA for both α‐ and β‐tryptase and also produced the protein, although at much lower concentrations than mast cells. However, the frequency of tryptase positive HRS‐cells in situ was very low. This report demonstrates that tumour cells of lymphoid origin can express tryptase in vitro and in situ .