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Pathological Survivin Expression Links Viral Infections with Pathogenesis of Erosive Rheumatoid Arthritis
Author(s) -
Bokarewa M.,
Tarkowski A.,
Magnusson M.
Publication year - 2007
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2007.01977.x
Subject(s) - survivin , rheumatoid arthritis , pathogenesis , immunology , inflammation , cancer research , medicine , transcription factor , proinflammatory cytokine , arthritis , biology , gene , cancer , biochemistry
Rheumatoid arthritis (RA) is an inflammatory joint disease leading to cartilage and bone destruction. Insufficient apoptosis in the inflamed RA synovium along with accumulation of highly differentiated B‐ and T‐lymphocytes as well as invasive growth of macrophages and fibroblasts is among the major mechanisms supporting joint destruction. We have recently shown that circulating survivin, an apoptotis inhibitor tightly bound to tumorigenesis, is an independent predictor of development and progression of joint destruction in RA. In this review we discuss the possible connectivity between viral infection, leading to interferon (IFN)‐alpha production, survivin expression, and subsequent joint inflammation. The role of IFN‐α and the involvement of IFN transcription factors and phosphoinositide‐3‐kinase signalling as essential modulators of arthritogenic process are discussed in the context of survivin.