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Patterns of In vitro Lymphoproliferative Responses Among HTLV‐1‐infected Subjects: Upregulation by HTLV‐1 During HIV‐1 Co‐infection
Author(s) -
Olah I.,
Fukumori L. M. I.,
Montanheiro P.,
Vergara M. P.,
Smid J.,
Duarte A. J. S.,
Penalva de Oliveira A. C.,
Casseb J.
Publication year - 2007
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2007.01941.x
Subject(s) - asymptomatic , lymphoproliferative response , peripheral blood mononuclear cell , in vitro , virology , human t lymphotropic virus 1 , immunology , medicine , asymptomatic carrier , virus , human t lymphotropic virus , downregulation and upregulation , antigen , biology , gene , biochemistry , myelopathy , psychiatry , spinal cord , t cell leukemia
The present study evaluated the in vitro response to different mitogens and a candidin antigen (CMA) in Human T‐cell lymphotropic virus type 1 (HTLV‐1) and co‐infected HIV‐1/HTLV‐1 patients, to identify if this co‐infection may modify the spontaneous lymph proliferative response. Peripheral blood mononuclear cells from 72 healthy seronegative controls, 75 asymptomatic HTLV‐1‐infected carriers, 42 HAM/TSP cases, 33 solely HIV‐1‐infected subjects and 24 HIV‐1/HTLV‐1 patients were assayed in the presence and absence of mitogens (PHA, PWM and OKT3) and CMA. The HAM/TSP group had the highest proliferation rate at 3 and 6 days after culture. HAM/TSP cases showed decreased response to PHA, compared with asymptomatic HTLV‐1 subjects, and most important, the co‐infected HIV‐1/HTLV‐1 cases presented a similar response to HTLV‐1‐infected subjects after 3 days of culture. The singles HIV‐1‐infected group had decreased in vitro response. It appears that during co‐infection, the HTLV‐1 regulatory proteins overwhelm the action of HIV‐1 regulatory proteins.