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Treatment with anti‐TNF α does not induce reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice
Author(s) -
Van Diepen A.,
Martina C. A. E.,
Flierman R.,
Janssen R.,
Van Dissel J. T.
Publication year - 2007
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.2007.01920.x
Subject(s) - salmonella , salmonella enterica , serotype , tumor necrosis factor alpha , salmonella infection , microbiology and biotechnology , virology , biology , neutralization , intracellular , immunology , bacteria , antibody , genetics
Therapy with tumour necrosis factor‐ α (TNF α )‐blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNF α did not result in reactivation of infection, suggesting only a minor role for TNF α during latency of persistent Salmonella infection.