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Sehistosoma Mansoni in the Baboon: Modulation of Pathology After Vaccination with Polyclonal Anti‐Idiotypic Antibodies
Author(s) -
NYINDO M.,
BORUS P. K.,
FARAH I. O.,
OGUYA F. O.,
MAKAWITI D. W.
Publication year - 1995
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1995.tb03706.x
Subject(s) - baboon , vaccination , schistosoma mansoni , schistosomiasis , polyclonal antibodies , antibody , granuloma , immunology , biology , virology , pathology , medicine , helminths , endocrinology
Vaccination of five baboons with an anti‐idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated vaccine. Vaccination with the anti‐idiotypic antibodies resulted in a significant reduction of pathology and granuloma size following challenge with live unattenuated cercariae. Results presented in this work are considered highly significant because the anti‐idiotypic vaccine markedly influenced schistosomiasis morbidity which is the main consideration in this disease.