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Proliferation of IL‐2 Activated Lymphocytes Preferably Occurs in Aggregates by Cells Expressing the CD57 Antigen
Author(s) -
VOLLENWEIDER I.,
LAZZARATO M.,
GROSCURTH P.
Publication year - 1995
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1995.tb03671.x
Subject(s) - microbiology and biotechnology , cell , cell division , cell growth , antigen , biology , chemistry , immunology , biochemistry
Aggregates of lymphocytes were investigated in long‐term cultures of IL‐2 stimulated peripheral blood mononuciear cells. Cells in clusters formed broad contact areas where coated pits and vesicles were often detectable. Proliferating cells were preferably found in aggregates indicating that the cell clusters represent proliferation centres in which cell division may be promoted by accessory signal transduction mediated by the close cell‐to‐cell contact. In bulk cultures CD57+ cells yielded increased proliferation capacity compared to CD57‐ cells. In addition, CD57+ cells were preferably localized in aggregates where they occupied the same position at the periphery of the clusters than the proliferating cells, suggesting that both cell types may be identical. It is discussed that the CD57 antigen represents a differentiation marker which is upregulated when CD57‐ cells start to proliferate assisted in cell aggregates.