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Impact of MHC Class I Gene on Resistance to Murine AIDS
Author(s) -
MAKINO M.,
MURPHY D. B.,
MELVOLD R. W.,
HARTLEY J. W.,
MORSE H. C.
Publication year - 1995
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1995.tb03669.x
Subject(s) - gene , biology , transgene , lineage (genetic) , major histocompatibility complex , genetically modified mouse , mhc class i , strain (injury) , microbiology and biotechnology , virology , recombinant dna , gene product , genetics , gene expression , anatomy
Development of murine AIDS in mice following infection with LP‐BM5 murine leukaemia virus (MuLV) is highly strain dependent, with strain differences determind by genes within and outside H‐2. Among H‐2 genes, the D d gene is the most closely associated with resistance to LP‐BM5 MuLV infection. However, the D d ‐mediated resistance is highly influenced by outside H‐2 genes, i. e. A lineage strains are more resistant than mice strains of B6/B10 lineage. In this study, the mice having BALB background were analysed and, similarly to A lineage mice, only D d gene products were found to be required to provide resistance to LP‐BM5 MuLV infection. Furthermore, BALB/c Kh mice bearing both D d and L d genes clearly showed obviously higher resistance than BALB/c‐H‐2 dm2 mice solely having the D d gene. In addition, in the long‐term observation of the effect of the D d gene on B6/B10 background mice, D8 mice having the D d gene as a transgene and expressing a high level D d gene product showed higher resistance than naturally recombinant B10. A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene.