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Interleukin‐4 Induces In Vitro Migration in Naive B Cells Through Direct Mechanisms
Author(s) -
CLINCHY B.,
MOLLER G.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03485.x
Subject(s) - in vitro , chemotaxis , microbiology and biotechnology , biology , cytokine , immunology , interleukin 4 , naive b cell , cd40 , chemistry , cytotoxic t cell , receptor , biochemistry
Interleukin‐4 (IL‐4) mediated locomotor responses by marine B cells in vitro were examined in this paper. The IL‐4 induced migration was found to act directly on purified, splenic B cells, without involvement of secondary mediators. It appeared that only a subpopulation of B cells was able to respond in migration assays. Flowcytometric analysis showed that the migrating cells had the characteristics of naive B cells: I‐A 10 , J 11d hi , IgD hi . They also displayed high expression of the adhesion molecule L‐selectin and made predominantly IgM antibodies. This is contrary to what has previously been observed regarding motile responses to chemotactic factors by T cells, which mostly affect memory or activated T cells. However, this is in accordance with other studies indicating that IL‐4 is a cytokine that exerts its effect mainly on resting B cells.