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Vδ1 + Gamma/Delta T Lymphocytes Infiltrating Human Lung Cancer Express the CD8α/α Homodimer
Author(s) -
FERRARINI M.,
HELTAI S.,
CHIESA G.,
SABBADINI M. G.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03475.x
Subject(s) - cd8 , biology , intraepithelial lymphocyte , t cell receptor , compartmentalization (fire protection) , phenotype , cytotoxic t cell , microbiology and biotechnology , immunology , lung , t cell , cancer research , immune system , gene , genetics , medicine , biochemistry , enzyme , in vitro
Murine γ/δ T lymphocytes localize to different epithelial tissues and are phenotypically distinct from peripheral γ/δ T cell‐populations in that they show limited TCR diversity, express the CD8 α/α homodimer and lack the CD8β chain. In humans, a compartmentalization of γ/δ cells sharing similar phenotypic features has been documented to date only in the case of intestinal epithelium. In the present study we show that about half of Vδ1 + (as well as Vδ1 − Vδ2 − ) γ/δ lymphocytes, which can be selectively expanded from human lung cancers, coexpress the CD8α/α homodimer. The accumulation of intraepithelial CD8 + γ/δ + lymphocytes might then be a more general phenomenon, possibly as a result of common mechanisms operating at those sites.