Premium
A Human Rheumatoid Factor C304 Shares V H and V L Gene Usage with Antibodies Specific for Ubiquitous Human Viral Pathogens
Author(s) -
RIOUX J. D.,
RAUCH J.,
SILVESTRI L.,
NEWKIRK M. M.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03472.x
Subject(s) - rheumatoid factor , gene , antibody , rheumatoid arthritis , germline , biology , immune system , virology , genetics , immunogenetics , gene expression , immunology , virus , microbiology and biotechnology
Analysis of the variable region getie sequetices of a human hybridoma rheumatoid factor (RF), derived from a patient with rheumatoid arthritis (RA), revealed the expression of genes from the V β I and V H 3 families. Specifically, the C304 RF had rearranged the DPL8/Humlv1042 and VH26 germline V L and V H genes, respectively. This gene usage has been observed in the rearrangement of human anti‐viral antibodies specific for the herpes group of viruses. This overlap between the autoimmune and anti‐viral antibody gene repertoires suggests a possible structural relationship between the immune response directed against ubiquitous pathogens and the induction of RF production.