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High Serum‐Soluble Interleukin‐2 Receptor is not Associated with the Immunosuppression in Diffuse Cutaneous Leishmaniasis
Author(s) -
AKUFFO H.,
MAASHO K.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03406.x
Subject(s) - immunosuppression , cutaneous leishmaniasis , immunology , leishmaniasis , interleukin 2 , visceral leishmaniasis , medicine , leishmania , antigen , leishmania major , serial dilution , peripheral blood mononuclear cell , cytokine , in vitro , biology , pathology , parasite hosting , biochemistry , alternative medicine , world wide web , computer science
Diffuse Cutaneous Leishmaniasis (DCL) is a rare complication of Leishmania aethiopica ‐induced cutaneous leishmaniasis which is associated with non‐self healing and in vivo and in vitro antigen‐specific non‐responsiveness. Such antigen‐specific unresponsiveness is also observed in visceral leishmaniasis (VL). The non‐responsiveness seen in VL disease is believed to be due, in part, to serum‐derived factors, including raised serum soluble IL‐2 receptor (sIL‐2R). Raised sIL‐2R in serum was not a consistent feature of DCL in our study (range: 787–4546 U/ml) but was frequently observed in sera of patients with other dermatological disorders (range: 474–3313 U/ml) and some patients with the simple local cutaneous leishmaniasis (LCL; range: 556–4247 U/ml). The level of sIL‐2R in the sera of DCL patients was not indicative of the disease state. Sera from DCL patients did not reduce proliferation of the IL‐2‐dependent CTLL cell line nor reduce PHA‐driven mononuclear cell proliferation, although sera from VL patients could. Both DCL and VL sera could reduce the L. aethiopica ‐driven proliferation. Furthermore addition of serial dilutions of recombinant IL‐2 to CTLL cultured in VL or DCL sera containing high sIL‐2R levels did not alter the effect of such sera on proliferation. We conclude therefore, that raised sIL‐2R in serum is not associated with the immunosuppression in DCL.