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The Treatment of Autoimmune Disease in (NZB/NZW)F1 Mice with Syngeneic Photomodulated Splenocytes
Author(s) -
LIN R.H.,
WANG L.F.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03399.x
Subject(s) - autoantibody , splenocyte , immunology , autoimmune disease , spleen , antibody , disease , medicine , in vitro , glomerulonephritis , biology , endocrinology , kidney , biochemistry
(NZB X NZW)FI (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double‐stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high‐titre IgG anti‐dsDN A antibodies. The function of the autoreactive T cells in vitro , however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoanti‐body‐rciated autoimmune diseases.